Cell therapy, particularly using cardiomyocytes, shows significant promise for treating heart failure. Direct reprogramming of somatic cells into cardiomyocytes using small molecules is advantageous ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

Manipulating cell identity through transcription factor-mediated reprogramming, induced pluripotency or directed differentiation holds promise for disease modelling and regenerative medicine. Yet the ...

Scientists have taken a small but significant step toward testing the idea of reverse aging in humans. Researchers have ...

Test time has arrived: the first person has been treated in a highly anticipated gene therapy trial that aims to coax aged cells to take on a younger identity. The clinical trial will test a novel ...

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

Harvard Stem Cell Institute (HSCI) researchers, representing five Harvard departments and affiliated institutions as well as the Massachusetts Institute of Technology (MIT), have demonstrated that ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...

A team of health and medical researchers affiliated with a host of institutions across Sweden has tested the possibility of reprogramming cancer cells into cDC1 cells as a means for destroying the ...

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the "recipe" for the transformation. Researchers at Lund University have now created ...