Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a ...

Promising mouse studies and billions of dollars in funding are stoking excitement. But we’ve been here before.

Decoding and reprogramming cells — the fundamental units of life — remains one of the most profound challenges in modern biology. Historically, the identity of a differentiated cell was viewed as ...

Aging, at its most fundamental level, is a molecular process. Chemical marks on the genome shift and lose fidelity over time, ...

EPFL researchers have uncovered how transcription factor dosage reshapes cell identity, showing that even small differences in dose can steer cells toward completely different fates. Their findings ...

Personalized disease treatment, tailored to an individual’s genetic background, is the future of medicine. Stem cells hold the promise of that objective becoming a reality. A decade ago, the discovery ...

A team led by researchers at the University of Toronto has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of ...

A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

In a breakthrough for longevity science, a reverse-aging treatment has been injected into a human. The technique is a sought-after solution for improving longevity by reprogramming cells. Competitors ...