The field of spatial transcriptomics utilizes technologies that map gene expression data to specific cellular locations within tissues. While traditional RNA sequencing methods generate quantitative ...

Spatial transcriptomics is a technique that provides information about gene expression patterns within intact tissues. This technology employs various methodologies, including in situ sequencing (ISS) ...

As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research. To deeply investigate ...

In spatial transcriptomics, tissue samples are randomly positioned. Rotation-sensitive methods can lead to unreliable spatially variable gene (SVG) detection. We highlight their inherent technical ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Spatial biology is a rapidly advancing discipline that examines biological molecules (such as DNA, RNA, and proteins) within their native locations in tissues. This approach offers critical insight ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Spatial proteomics is rapidly emerging as a transformative method in life science and biomedical research, offering scientists the ability to visualize protein expression within intact tissue ...